Ishizu works for the Egyptian supreme council of antiquities and possessed the [[Millennium Necklace|Millennium Tauk]], which gave her the power of foresight. Ishizu is from a family of [[Tomb Keeper|Tomb Guardians]]. She became disconnected from her brother, [[Marik Ishtar (manga)|Marik]] and the family servant [[Rishid (manga)|Rishid]], after Marik's hatred manifested into the destructive entity, [[Dark Marik (manga)|Dark Marik]]. Ishizu aimed to defeat Dark Marik and restore save Marik to his former self at any cost. Using As part of her position in the Egyptian supreme council of antiquities and the foresight powers of the [[Millennium Necklace|Millennium Tauk]]plans, Ishizu was able to combat Dark Marik's plans to acquire the [[Egyptian God|God cards]]. She convinced she coerced [[Seto Kaiba (manga)|Seto Kaiba]] to host to [[Battle City]] tournament, coercing with the prospect of him acquiring the [[Egyptian God|God cards]], despite foreseeing his failure. However when Kaiba defeated her in the tournament, she became optimistic that the future could be changed.