The easiest way to use this card's effect would be to ram it into an opponent's low-ATK monster (perhaps by first reducing that monster's ATK).
Use a card like "Darkworld Shackles" to reduce an opponent's monster's ATK to a reasonable amount. This also allows that monster to be easily destroyed later after you use this card.
For optimal results, Summon (up to) 3 copies of "White Duston" and 2 copies of "House Duston" to your side of the field, while Summoning the other members of the "Duston" archetype with their negative effects to your opponent's side of the field.
You can reuse this card's effect by Special Summoning it via "Kinka-byo".
"Goblin King" works well with this card's effect. Since all "Duston" monsters are Fiend-Type, "Goblin King" can potentially reach 8000 ATK.
Use cards like "Ceasefire" and "Just Desserts" to burn your opponent for extremely large quantities of damage at once.
As an alternative strategy, this card can be used as a Deck thinner, since it can thin your Deck by up to 10 cards at once, although you should be careful with the "Duston" monsters' negative effects.