This card's artwork is an allusion to the artwork of "Polymerization", which features a similar artwork featuring a swirling background with a stylized dragon and demon circling together.
This card has a redundant restriction text; as the player cannot Special Summon other monsters during the turn this card is activated, this also means that the player could not activate another copy of "Red-Eyes Fusion" by default, thereby rendering the once per turn restriction redundant.