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Greiger appears exclusively as a Dark Signer in this game.
The player faces Greiger as the third of the Dark Signers. He forces the player into a Turbo Duel, and demands to be defeated only after his Earthbound Immortal, "Cachu Challhua", is summoned. Doing so will let the player continue with the storyline.
After finishing the game, the player can Turbo Duel against Greiger as the first opponent of the dark miasma duel gauntlet located in the B.A.D. area.