|Organization||Knights of Hanoi|
|Anime debut||Yu-Gi-Oh! VRAINS episode 22: "The Deleted"|
Dr. Genome (ドクター・ゲノム Dokutā Genomu) is a character appearing in the Yu-Gi-Oh! VRAINS anime, and a member of the Knights of Hanoi.
Genome is a pale-skinned man with orange eyes and green hair that stick out in bean-like clumps. He wears large round spectacles with orange frames shaped in a similar manner to his hair. He wears a green jacket over a white shirt, white pants, and orange shoes. When he was younger, his hair was sharper and more organized, his glasses lacked their "horns", and his cheeks less dimpled. He wore a lab coat over a charcoal shirt.
In LINK VRAINS, Genome's hair spikes up and gains a darker green underlayer. He exchanges his spectacles for a steel eyepiece similar to that worn by Faust and Baira, with a small red lens over his eye that is surrounded by two gold lines, has a diamond shaped portion over his nose set with a green gem, and four fin-like portions each with a gold line in the center. He dresses similarly to Faust, with a white trench coat that is cut back from the style of his fellow Knights that is lined with turquoise and dark blue and has dark blue cords holding it closed over his chest, a white shirt with a black fastening strip down the center, white flared military pants, and calf-length white boots with turquoise cuffs.
Genome aided Kiyoshi Kogami with his Ignis project, alongside Faust and Baira. After Kogami's death, the three helped Kogami's son, Ryoken form the Knights of Hanoi to avenge Kogami's death and prevent the Ignis from destroying humans. He participated in the attack on the Cyberse alongside his fellow Knights.
Genome plays a "Helixx" Deck. His strategy involves summoning high Level monsters without Tribute and using them for Link Summons, while also focusing on defensive effects.