- You can activate this card, then summon "Asura Priest", equip it with "Big Bang Shot", and attack each of your opponent's monsters. This combo will deal 2100 damage per destroyed monster.
- You can use this card with your "Dream Clown" or "Blade Rabbit" to destroy a monster on your opponent's side of the field.
- You can also combine this card with "Tragedy" to destroy effect monsters on your opponent's side of the field.
- During the turn you intend to use this card and you want to use your effect monster, activate "Curse of Anubis'" effect before you Summon the effect monster. If the effect monster you summoned has a Piercing effect, even better.
- This card is great against "Cloudian" monsters as many of them are destroyed as soon as they are in Defense Position.
- You can couple this card with "Burst Breath". Because "Curse of Anubis'" effect reduces effect monsters' DEF to 0, you can tribute any Dragon-Type monster and it will always destroy all of your opponent's monsters affected by "Curse of Anubis".
- Use this card with "Dark Mirror Force" when an opponent attacks.
- You can use this card along with "Meteorain" to deal easy damage to your opponent.
- Combo this card with "Elemental Hero Wildheart" or "Tenkabito Shien".
- This card works well with "Dark Blade" equipped with "Pitch-Dark Dragon". Even though "Pitch-Dark Dragon" is giving "Dark Blade" a trample effect it's is still a Normal Monster so it won't be affected by "Curse of Anubis", and since the effect monsters have 0 DEF it'll deal 2200 damage when it attacks one.
- Use this card, then Fusion Summon "Elemental Hero Wildedge" and equip it with "Fairy Meteor Crush" to deal heavy damage.
- After you have used this card, Summon "Twin-Sword Marauder" to Destroy 2 of your opponent's Monsters and deal 3200 points of Battle Damage.
- This card works well with Doom Donuts as it destroys all monster with original atk or def of 0, but it still affects you face up monsters.