- "Generation Shift" can be used to trigger the Manticore of Darkness loop.
- Generation Shift will work extremely well with Crystal Beast, because it says 'destroy' not 'Tribute', and so moves your chosen Crystal Beast to the back row, and gives you another.
- This card works well in "Fortune Lady" decks. Summon "Fortune Lady Light", then activate this card to trigger the monster's effect. Then gain another "Fortune Lady Light" from your deck.
- This card works well with "Sacred Phoenix of Nephthys". Destroy "Sacred Phoenix of Nephthys" to bring out another "Sacred Phoenix of Nephthys". During your next standby phase the destroyed "Sacred Phoenix of Nephthys" will return to the field, activating its effect.
- This card works well with "Harpies".
- Use this card with "Darksea Float" to draw 1 card.
- This card works well in an Archfiend Deck Deck with Pandemonium, because your hand can start to fill up with Archfiend monsters that you can play as a combination (such as Vilepawn Archfiend with Infernalqueen Archfiend, especially with Ultimate Offering.
- Use this card when Macro Cosmos or Dimensional Fissure is on the field with your D.D. Survivor and D.D. Scout Plane. If you hadn't summoned or have the ability to summon (through other card's effects), then this gives you swarming ability, since the destroyed card can simply return at your End Phase.
- This card works well with "Tech Genus"; chain it to your opponent remove from play or steal effects. Not only you trigger the Tech Genus effect, you'll gain another copy of the monster in your hand.