During your Battle Phase, after you attack with this card, you can return this card to your hand with "Compulsory Evacuation Device", then in your Main Phase 2 you can discard it to use its effect.
Or, you can use "Begone, Knave!" to return it to your hand after attacking.
"Deck Devastation Virus" can be used instead to destroy your opponent's monsters with ATK equal and lower to 1500.
You can return this card from your Graveyard to your hand with "Recurring Nightmare".
Note that the monsters you can summon alongside "Plaguespreader Zombie"/"Pain Painter" are Level 3, 4 and 5, allowing you to easily Synchro summon a Level 5, 6 or 7 Synchro monster respectively.
This card works well in "Skull Flame" decks, as you can summon two "Burning Skull Heads" and sacrifice them for a "Skull Flame", dealing 2000 damage and getting out a 2600 ATK beatstick.
This card can also be used in a "Ghostrick" deck to summon "Ghostrick Jiangshi" and "Ghostrick Stein" to quickly summon a Rank 3 monster, like "Ghostrick Alucard".