- You can use this card's first effect by returning "Swords of Revealing Light", then replay it right after. If you continue this turn after turn, this creates a continuous attack lock for your opponent, making them unable to attack you unless they get rid of either "Cosmos Fortress Gol'Gar" or "Swords of Revealing Light".
- This card works great in conjunction with ""A" Cell Incubator", regenerating the A-Counter used for its second effect instantly. You can either simply remove a counter from the Incubator to get a free destruction, or remove a counter from a monster you're going to destroy with the effect to gain one for use if the Incubator is destroyed later.
- Return ""A" Cell Breeding Device", "Mass Hypnosis", or "Brainwashing Beam" to your hand for this card after spending their effects, allowing you to set or play them again for next turn.
- To bring this card into play quickly, you can activate "Snake Rain" or "Foolish Burial" to send a Level 4 Alien Monster to your Graveyard, then Special Summon that monster with "Alien-Monite", giving you the required monsters to Synchro Summon right away.
- Since you can place the A-Counters from this card's effect on cards on your side of the field, you can use this to infinite refresh the A-Counters on a monster you took control of with "Brainwashing Beam" or "Alien Hypno".
- This card can work well in a venom deck, each turn returning Venom Swamp, Damage = Reptile, etc.while also powering up Vennominon the King of Poisonous Snakes, Vennominaga the Deity of Poisonous Snakes, or Evil Dragon Ananta.
- You can Set all Spell and Trap Cards in your hand and use its effect to return them all to your hand once per turn, distributing A-Counters for no cost.
- Use Chain Energy with this card, to make your opponent pay 500 lifepoints for every card they play from their hand while you return it to your hand on your turn so you don't have to pay anything. Also use Spell Absorption with this card to be capable of gaining large amounts of lifepoints every turn.
- Use Limit Reverse with this card. Limit Reverse is only destroyed when the monster is destroyed, so if you use the monster with Limit Reverse attached to it for a Synchro Summon or a tribute, it will stay on the field and you can return it to your hand with Cosmos Fortress Gol'Gar to reuse again and again. You can do the same thing with Escape from the Dark Dimension to retrieve your out of play dark monsters.
- Use this card with Stumbling, Level Limit - Area B, Fairy Box, Gravity Bind, Ordeal of a Traveler, or Messenger of Peace to prevent your opponent from attacking, and return it to your hand on your turn so that you can still attack.
- Use this card with Chain Burst and Curse of Darkness to limit the number of spell and trap cards your opponent can/will play and deal damage to them for the ones they do play. You can also use Royal Oppression to stop your opponent from special summoning on their turn, but keep in mind it will prevent you from special summing on your opponent's turn as well. Similarly, you can use Toll to make your opponent pay to attack, while you didn't have to.