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* Use this card on "[[Ultimate Axon Kicker]]" to give him even greater immunity, and his effect will negate this card's destructive drawback, while "[[Ultimate Axon Kicker]]" doesn't need direct attacking to perform well.
** This also works with "[[Koa'ki Meiru Valafar]]".
* Use this card in combination with "[[Legendary Six Samurai - Shi En]]". This will create probably one of the most troublesome monsters for your opponent as it cannot be destroyed by card effect or battle and can negate cards that can destroy "[[Safety Safe Zone]]". Additionally, when "Safety Safe Zone" is destroyed, You can destroy another "[[Six Samurai]]" monster instead by "Shi En's" other effect.
* This card can combo well with "[[Scrap Dragon]]" and its counterparts. Select this face-down card and another card your opponent controls, then chain with this card and give it to an opponent's monster. Your opponent will need to waste another card to protect their monster. You get a 2-for-1 destruction.
* Use this card with an Attack draw monster like "[[Dupe Frog]]" or "[[Watthopper]]", with them and this card, your opponent will have a hard time attacking any of your monsters.
* Equip to an opponents monster and use "[[Mist Valley Falcon]]"'s effect to return "Safety Safe Zone" back to your hand, destroying your opponents monster.
* You can equip this card to a monster your opponent controls, then use "[[Uria, Lord of Searing Flames]]'s" [[Summoning Condition]] to send this card to the Graveyard in order to destroy that equipped monster.
* Use this card on "[[Naturia Bamboo Shoot]]" to have him immune to being destroyed (by card effects or by battle) and prevent his effect to be [[negate]]d by "[[Effect Veiler]]", thus never allowing your opponent to use [[Spell]] and [[Trap card]]s again for the rest of the Duel; unless they use cards such as "[[Neo-Spacian Grand Mole]]" or "[[Breaker the Magical Warrior]]".
* You can equip this card to [[Archfiend Zombie-Skull]] to make him practicaly imortalpractically immortal. With him on the feild field your zombie monsters cannot be destroyed by card effects. Even if this card is destroyed, his own effect protects him from getting destroyed making it troublesome for your opponent.
