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* This card can be [[Searcher|searched]] by "[[Rogue of Endymion]]", "[[Watch Cat]]", "[[Watch Dog]]", "[[The Despair Uranus]]", and other [[List of generic searchers#Spells|generic searchers]].
* "Dark Snake Syndrome" works well with "[[Des Wombat]]", as "Des Wombat" will prevent any [[effect damage]] you take. This results in your opponent taking all the damage from "Dark Snake Syndrome".
* Sadly you cannot use this card in conjunction with "[[Barrel Behind the DoorDark Snake Syndrome]]" or still doubles even when you don't take damage from cards like "[[Spell One Day of PainPeace]]". This ** You can also use "[[Life Stream Dragon]]" in advanced format only. This is due order to the Japanese translation designating the condition that these cards effects can only triggered by a opponent's effect. Otherwise, if stop it from damaging you are playing by traditional format, you could potentially win the duel in just 4 turns.
* If you can't keep "[[Des Wombat]]" alive on the field long enough to keep you from taking damage from this card, use "[[Pikeru's Circle of Enchantment]]" just before your [[Standby Phase]].
** Use "[[Solomon's Lawbook]]" only as a means to keep yourself from getting damage.However, skipping your Standby Phase will prevent the effect of "Dark Snake Syndrome " from activating at all, thus your opponent will not take damage either.
*** However if you run "[[Mist Body]]" in your deck and equip one to "[[Des Wombat]]" you will end up with the equivalent of a continuous version of "[[Pikeru's Circle of Enchantment]]".
*** If you are not able to protect your life points you should insure your opponent has less life points than you before you activate "[[Dark Snake Syndrome]]", and you have a "[[Mystical Space Typhoon]]" or "[[Twister]]" ready to destroy "[[Dark Snake Syndrome]]", avoiding a draw.
* This can be used in a stall deckDeck. If this card and "[[Prime Material Dragon]]" are on the field its possible to get quite a few life points per turn.** But the only draw back is that the opponent will gain this amount as well, unless you combat that with cards like "[[Bad Reaction to Simochi]]" or "[[Darklord Nurse Reficule ]]".** If "[[Prime Material Dragon]]" is not on the field, it can be easy to end the Fallen One[[Duel]] in a [[Draw]]".
* This card works well with "[[Black-Winged Dragon]]". Burning your opponent while you take no damage and "Black-Winged Dragon" gains counters for its effect.
* You can combine "Dark Snake Syndrome's" effect with cards such as "[[Gem Flash Energy]]" or "[[Dark Room Of of Nightmare]]"; thus whilst taking damage, your opponent will sustain more damage then than you. * In a [[D/D]] deck, use cards like "[[Contract Laundering]]" to regain life points, or "[[D/D/D Rebellious Overlord Leonidas]]" to avoid effect damage completely.
