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* Combo "[[D. Tribe]]" and/or "[[DNA Surgery]]" (declaring [[Dragon]]-[[Type]]) with "[[Scapegoat]]" to allow easy access to Fusion Materials.
** OR, you can forgo "Scapegoat" in the above combo and use your opponent's monsters instead, if you use "[[Super Polymerization]]"(Traditional Format).
*** OR, you could use "D. Tribe" and/or "DNA Surgery" (declaring Dragon-Type) with "Scapegoat" and "[[Fusion Gate]]" "[[Field Spell Card]]" on the [[field]], in order to Summon "Five-Headed Dragon" so effectively and effortlessly indeed.
* You can use "[[DNA Surgery]]" along with "[[Super Polymerization]]" to Summon "[[Five-Headed Dragon]]". Use "DNA Surgery" to declare all monsters on the field to Dragon-Type, then use "Super Polymerization" to either on your opponent's or your own monsters to bring out "Five-Headed Dragon". It is also very effective to use your opponent's monsters as Fusion Materials, so that way, they won't have any monsters to defend from a direct attack.
* Summoning this card can be useful for sending Dragons to the Graveyard to power up "[[Blue-Eyes Shining Dragon]]" or "[[Red-Eyes Darkness Dragon]]".
** Using nothing but Dragon [[Tuner monster|Tuner]]s can also power up "[[Red Nova Dragon]]".
** It can also power up "[[Cyberdark Dragon]]" and provide high-ATK monsters for "[[Cyberdarkness Dragon]]".
== Traditional Format ==
* This is a great card to use as a Tribute for "[[The Tyrant Neptune]]", as it can gain this card's ATK and effect. Tributing "[[Hardened Armed Dragon]]" in addition to this combo will grant "The Tyrant Neptune" additional protection.
* "[[Dimension Fusion]]" or "[[Return from the Different Dimension]]" can be used to Summon the Fusion Materials that were banished by "Dragon's Mirror".* In a [[Dragon Ruler]]/[[Lightsworn]] Deck, you can Special Summon all 4 of the Dragon Rulers after using "[[Judgment Dragon|Judgment Dragon's]]" effect to destroy all other cards on the field. After attacking with them(Or not, if their LP is already 5000 or less), you can Fusion Summon this card with "[[Flash Fusion]]" and attack directly for an OTK.** You can also banish all 5 of them with "[[Dragon's Mirror]]" to summon this card.
