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→Trivia: Expanded on a piece of trivia
** It also is the first series to lack [[Battle Royale]] Duels and 2 v 2 Tag Duels, though it featured 1 v 2 Tag Duels.
* ''Yu-Gi-Oh! VRAINS'' is the first anime series whose English theme song lacks lyrics since ''[[Yu-Gi-Oh! (anime)|Yu-Gi-Oh!]]''.
**While the opening theme for ''[[Yu-Gi-Oh! (anime)|Yu-Gi-Oh!]]'' has no lyrics, it does contain verbal words in the form of dialogue from Yami Yugi while the opening for ''Yu-Gi-Oh! VRAINS'' does not contain any verbal words at all and instead contains a chorus.
* ''Yu-Gi-Oh! VRAINS'' is the first anime series not to have a manga counterpart.
* ''Yu-Gi-Oh! VRAINS'' is the last series to have [[Studio Gallop]] as the head animators for the series. The following series, ''[[Yu-Gi-Oh! SEVENS]]'', has [[Bridge]] now serving as the primary animation studio.
