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* Yusasku is one of two anime protagonists to have never lost a Duel within the present main storyline, the other being [[Yusei Fudo|Yusei]].
* In early plans for ''Yu-Gi-Oh! VRAINS'', Yusaku was going to be a newcomer to ''Duel Monsters'', which would have fit the show's original theme of "Take a step forward and try".{{citation needed}} This was changed before the series was released.
* Yusaku is the first main protagonist whose Deck centers around a new monster Type (in this case, Cyberse).
* Yusaku is the first main protagonist since [[Yugi Muto|Yugi]]:
** To have three different colors in his hairstyle's design.
** To use a non-Dragon/Warrior monster as his Whose [[Signature card|ace monster]]'s Type is neither Warrior (like Jaden and [[Yuma Tsukumo|Yuma]]) nor Dragon (like Yusei and [[Yuya Sakaki|Yuya]]).
** To successfully perform a [[Ritual Summon]].
* Yusaku is the first main protagonist since Jaden:
** Both were once considered criminals in their series.
** Both have only lost Duels in flashbacks that take place prior to the beginning of their series.
** Both have never been turned evil at any point in their series like the other main protagonists, though [[Yuma Tsukumo|Yuma]] never actually turned evil as Astral embraced evil power and merged with him into Dark ZEXAL.
* Yusaku and Yusei also both have similar monsters in their Decks.
** Warrior-themed secondary ace monsters with a DARK Attribute, 2300 ATK, and offensive effects that focus on gaining strength from other monsters ("Decode Talker" and "[[Junk Warrior (anime)|Junk Warrior]]").
** Effect Monsters that can Special Summon a Level 2 or lower monster from its controller's Graveyard in Defense Position, but with its effects negated, upon being Normal Summoned ("Cyberse Gadget" and "[[Junk Synchron (anime)|Junk Synchron]]").
