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* Yusasku is one of two anime protagonists to have never lost a Duel within the present main storyline, the other being [[Yusei Fudo|Yusei]].
* In early plans for ''Yu-Gi-Oh! VRAINS'', Yusaku was going to be a newcomer to ''Duel Monsters'', which would have fit the show's original theme of "Take a step forward and try".{{citation needed}} This was changed before the series was released.
* Yusaku is the first main protagonist whose Deck centers around a new monster Type (in this case, Cyberse).* Yusaku is the first main protagonist since [[Yugi Muto|Yugi]]:
** To have three different colors in his hairstyle's design.
** Whose [[Signature card|ace monster]]'s Type is neither Warrior (like Jaden and [[Yuma Tsukumo|Yuma]]) nor Dragon (like Yusei and [[Yuya Sakaki|Yuya]]).
** To successfully perform a [[Ritual Summon]].
* Yusaku is the first main protagonist since Jaden:
** To use [[Field Spell Card]]s in his Deck.
** To not have his father be central to the plot of his series.
* Yusaku is the first main protagonist since Yusei to use [[Normal Monster]]s in his Deck.* Yusaku is the only main protagonist:
** Who has never had a Duel end with no result.
** Who has never lost a Duel to another human.
** Both were once considered criminals in their series.
** Both have only lost Duels in flashbacks that take place prior to the beginning of their series.
** Both have never been turned evil at any point in their series like the other main protagonists, though Yuma never actually turned evil as Astral embraced evil power and merged with him into Dark ZEXAL.
* Yusaku and Yusei also both have similar monsters in their Decks.
** Dragon-themed primary ace monsters with 2500 ATK and defensive effects that focus on protecting other cards ("Firewall Dragon" and "[[Stardust Dragon (anime)|Stardust Dragon]]").
