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** Not have a manga counterpart.
** Lack [[Battle Royale]] Duels and 2 v 2 Tag Duels, though it featured 1 v 2 Tag Duels.
* This is the first anime series since ''[[Yu-Gi-Oh! (anime)|the originalDuel Monsters]] '' whose English theme song lacks lyrics.
** While the opening theme for ''Yu-Gi-Oh!'' has no lyrics, it does contain verbal words in the form of dialogue from Yami Yugi, whereas the opening for ''Yu-Gi-Oh! VRAINS'' does not contain any verbal words at all and instead contains a chorus.
* This is the last anime series to have [[Studio Gallop]] as the head animators for the series. The following series, ''[[Yu-Gi-Oh! SEVENS]]'', has [[Bridge]] now serving as the primary animation studio.
