Dr. Genome

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Dr. Genome
Dr. Genome
  • Dr. Genome
RōmajiDokutā Genomu
  • Male
  • Career
OrganizationKnights of Hanoi
  • Duelist
Anime DeckHelixx
Anime debutYu-Gi-Oh! VRAINS episode 22: "The Deleted"
Appears in
AnimeYu-Gi-Oh! VRAINS
Voice actors
  • Takuya Kirimoto[1]
Genome, Dr.

Dr. Genome (ドクター・ゲノム Dokutā Genomu) is a character appearing in the Yu-Gi-Oh! VRAINS anime, and a high-ranking member of the Knights of Hanoi. He was one of the scientists who worked on the Hanoi Project.



Genome is a pale-skinned man with orange eyes and green hair that stick out in bean-like clumps. He wears large round spectacles with orange frames shaped in a similar manner to his hair. He wears a green jacket over a white shirt, white pants, and orange shoes. When he was younger, his hair was sharper and more organized, his glasses lacked their "horns", and his cheeks less dimpled. He wore a lab coat over a charcoal shirt.

In LINK VRAINS, Genome's hair spikes up and gains a darker green underlayer. He exchanges his spectacles for a steel eyepiece similar to that worn by Faust and Baira, with a small red lens over his eye that is surrounded by two gold lines, has a diamond shaped portion over his nose set with a green gem, and four fin-like portions each with a gold line in the center. He dresses similarly to Faust, with a white trench coat that is cut back from the style of his fellow Knights that is lined with turquoise and dark blue and has dark blue cords holding it closed over his chest, a white shirt with a black fastening strip down the center, white flared military pants, and calf-length white boots with turquoise cuffs. When he uses his Skill, the gold lines on his eyepiece light up.


Genome, as his name would indicate, is obsessed with DNA and believes that it influences an individual's Dueling. As such, he is doubtful that someone can change their strategies nor fight their fate. He expressed a desire to study Playmaker's DNA and that of Grim Gore. Though disrespecting to his opponents, claims that he and his organization are people of honor, and as promised he gives the cure to Mackendrick Kellenbocker's Deleted virus to Gore after being defeated. As with many of the Knights of Hanoi, he is somewhat sadistic, with a constant sneer on his face.

Despite this, Genome does possess some nobility; he is disgusted by Lightning's actions and horrified when he realizes that the revenge of the Knights of Hanoi was misplaced. The Neuron Link also horrifies him, though he later admits excitement at the opportunity to analyze it.



A younger Genome working with Aso, Clarissa and Kiyoshi Kogami on the Ignis project.

Genome aided Kiyoshi Kogami with his Ignis project, alongside Aso and Clarissa Turner.[2] After Kogami's death, the three helped Kogami's son, Ryoken form the Knights of Hanoi to avenge Kogami's death and prevent the Ignis from destroying humans.[3] He participated in the attack on the Cyberse alongside his fellow Knights.[4]

Knights of Hanoi[edit]

After Varis and Dr. Kogami planted the seed of the Tower of Hanoi, Genome began attempting to track down Playmaker using the little information they could find on him. He targeted individuals with both hacking and Dueling experience that owned older models of Duel Disk, infecting them with Baira's Deleted virus. One victim was Mackendrick Kellenbocker, and after Genome infected him, he encountered Mackendrick's friend, The Gore. Observing that The Gore was a Celebrity Duelist, Genome introduced himself and explained what he had done to Mackendrick. He offered the cure to The Gore if he joined the Knights of Hanoi to hunt down Playmaker, but The Gore refused. Genome departed, telling The Gore to tell Playmaker to surrender to free the Deleted.

Playmaker later appeared in LINK VRAINS, defeating several Knights. Genome arrived, seeing through "Playmaker's" disguise and The Gore unmasked himself. Genome believed The Gore had come to join them, but Gore challenged Genome to a Duel for the removal program. He claimed to know Playmaker's identity, and though Genome doubted his claim, he agreed to the Duel, conjuring a Data Gale to allow them to Speed Duel.[1]

Dr. Genome knew that The Gore's tactic was to let his opponent gain the upper hand and then make a counterattack, like an entertainment style, which Gore confirmed. Genome summoned the powerful "Helixx Marmotroll", a turn that disappointed The Gore, who swiftly Link Summoned "Gouki Thunder Ogre". He used the monsters he used as materials to search his Deck for more "Gouki" cards, which Genome claimed to have anticipated anticipated. Gore equipped "Gouki Thunder Ogre" with "Gouki Dark Mask", and donned a mask himself, declaring that he would fight as a heel, dubbing himself "Grim Gore" and his monster "Dark Thunder Ogre". In addition, using "Gouki Poison Mist", Grim Gore spat out a purple liquid into Genome's face to damage him, then summoned "Gouki Riscorpio", destroying it to power-up "Dark Thunder Ogre" and damage Genome via the effect of "Dark Mask". Genome expressed a wish to sample Grim Gore's DNA and combine it with Playmaker's to create more powerful DNA, and Grim Gore responded by using his "Pain and Gain" Skill to revive "Gouki Riscorpio" and repeat his tactic, destroying "Riscorpio", inflicting effect damage to Genome, and boosting "Dark Thunder Ogre's" ATK to 3000, allowing it to destroy "Helixx Marmotroll", though the latter's effect protected Genome's LP from the battle damage. Grim Gore claimed he had evolved after his defeat against Playmaker and changed his battling style to a dark, heel one, that would do anything to win. Genome ignored this story, believing that Grim Gore's destiny was preordained by his DNA as it could not be changed. Resurrecting two of his "Helixx Mamortroll" with "Graveyard Incubation", Genome Link Summoned "Helixx Gothiclone", and had it attack "Dark Thunder Ogre". Both monsters could not be destroyed, and fell to the ground in a double knockout. Genome recalled that this had happened in The Gore's Duel against Playmaker as he used the effect of "Gothiclone", Genome Tributed "Helixx Dreadrat" and inflict its ATK to Grim Gore.[3]

Grim Gore swore to crush Genome for his belief that one's DNA imposed such limits, bringing out "Riscorpio" and "Gouki Twistcobra", then using the effect of "Twistcobra" to boost the ATK of "Dark Thunder Ogre" by Tributing "Riscorpio", and activating "Gouki Serpent Splash" to inflict the difference in ATK to Genome. Genome was able to counter it and Summon a "Helixx Token" with his "Regeneration Cure", then Link Summon "Helixx Necro Darwin" on his next turn. He destroyed "Twistcobra", which triggered Grim Gore's combo again, but this time Genome was protected from the combo by the effect of "Necro Darwin" that also doubled its ATK. "Gothiclone" clashed with "Dark Thunder Ogre" again, then Tributed "Necro Darwin" to inflict its increased ATK to Grime Gore. Grim Gore was blasted off his Duel Board, but saved himself by discarding "Gouki Octostretch" to halve the damage.[3]

Gore obtains the virus-removal program before Genome disappears.

Grim Gore climbed back on his Duel Board, but Genome revived "Necro Darwin" to active his "Minus Mitosis" Skill, cutting Grim Gore's LP and the ATK of "Dark Thunder Ogre" ATK in half and blasting Grim Gore through a wall with 100 LP left, barely able to stand on his Duel Board. As Gore's AI reminded him of Genome's tactics and explained that his odds of winning were low, Playmaker logged into LINK VRAINS. Genome asked if Playmaker had come to assist Gore, but Playmaker denied having come to help Grim Gore, claiming that he had come to mock him when he lost. Grim Gore's mask dissolved as The Gore used "Gouki Face Turn" to destroy "Gouki Dark Mask" and revive "Gouki Suprex", using it and "Thunder Ogre" to Link Summon "Gouki The Master Ogre". Gore revived "Twistcobra" and "Riscorpio", then returned them to his hand with the effect of "Master Gore" to negate Genome's "Hellix" monsters' effects, allowing "Master Ogre" to freely attack them, defeating Genome. Gore cheered for his victory, claiming the removal program from Genome. Genome was unamused by Gore's evolution, but Gore stated that it was only to amuse the crowd, as he was the number one entertainer. Genome swore Gore would regret defeating him before disappearing.[5]

After his defeat, Genome fell into a coma.[6] He was restored following Varis's loss to Playmaker during their second Master Duel.[7]


Three months after the events of the Tower of Hanoi, Genome, Specter, and Faust joined Varis in the Knights' control room. While the Knights had been building the Tower, the Cyberse had been destroyed and the Ignis scattered. Specter expressed confusion that his Ignis hadn't sought him out as the Fire Ignis had Theodore Hamilton, and Genome reminded him that they were trying to kill the Ignis, so of course it wouldn't seek him out. He expressed an interest in The Shepherd due to his hatred of A.I. and coding skills, though Varis claimed that they weren't on par with the Ignis or the Kogamis'. Genome was responsible for much of the plan to release Clarissa from prison, distracting the prison with a virus and then wiping their patterns from the security cameras, allowing them to walk right into the prison from their boat.[8]

Genome joined the other Knights of Hanoi in destroying Windy's fabricated Cyberse, defeating an Echo, while Varis rescued Playmaker and Ai from Lightning and Windy.[4][9] After defeating the Echoes, Genome, Baira and Faust entered Windy's palace to find Varis on 100 LP, though Genome believed that Varis would still win. He noted that the DNA-less Echoes had been surprisingly weak. Specter and Soulburner arrived and Lightning attempted to capture them, though the Fire Ignis, "Flame" blocked Lightning's efforts and freed Playmaker and Ai. Varis then defeated Windy, and ordered the Commanders to erase him. Genome and the other Commanders unleashed a virus that impaled Windy on spikes, but Lightning rescued him. Bohman and Harlin then arrived, and Lightning revealed Jin Kolter.[10] Lightning revealed that he had been behind the destruction of the Cyberse, though he admitted that they couldn't settle matters now due to Windy's infection. Genome proudly told Lightning that he and Baira had created the virus that would effectively destroy Windy's DNA at the roots and he reveled in Windy's impending destruction. Lightning declared war on humanity and fled, and Genome and the Knights remained in Windy's palace as Playmaker and Soulburner pursued Lightning, Bohman and Harlin. Varis decided to let Playmaker and SOL Technologies battle the Ignis for now, and ordered the Knights to let SOL Technologies know the Ignis' location.[11]

When Varis enacted his plan to use the Tower of Hanoi to scan for Lightning's location, Genome, Clarissa, and Aso remained on his speedboat to support Varis and Specter from the real world.[12] The Commanders' feed suddenly deactivated when the entrance to Mirror LINK VRAINS closed, and Genome started working on getting their connection back. Kolter sent them the feeds of Playmaker's team; Genome noted that he was a skilled hacker. They watched as Lightning approached Specter to Duel him, Genome declaring that they were counting on Specter. Lightning locked Specter down on the first turn with an Extra Link. Genome and Aso worried over whether Specter would be able to break the Extra Link, and Clarissa noted that they would have to trust Specter.[13] Specter was able to reverse the Extra Link, but Lightning defeated him and converted his Avatar into data.[14] Soulburner was able to defeat Windy and Flame absorbed his data, but Bohman defeated Blue Maiden and acquired hers, Aqua's, and Earth's data. Footage then showed Playmaker Dueling Kolter, and as Genome asked why Kolter was Dueling Playmaker, Clarissa received a program from Kolter to hack LINK VRAINS; Aso deduced that Kolter had anticipated being used by Lightning and had sent them the program as a result. Genome noted that it looked unfinished, though Clarissa was convinced they could complete it quickly by working together.[15] They finished the program just as Playmaker defeated Kolter.[16] The Commanders launched the program, destroying the barriers imprisoning everyone and Aso immediately contacted Varis. Varis reassured them he was all right and he asked Aso to send a message to Lightning, then to go to the Café Nom food truck in Den City to safeguard Kolter and work from there.[17][18]

Genome and Aso left Clarissa on Ryoken's speedboat and successfully found the van, where they found Kolter's comatose body and Genome noticed his monitor depicting Soulburner Dueling Bohman.[18] As Varis predicted, Lightning approached him, and Genome watched as Varis revealed that Lightning was the sole Ignis responsible for the Ignis turning against humanity in Dr. Kogami's simulations.[19] Varis was able to corner Lightning, but before he could declare his final attack, Lightning held Jin's data hostage.[20] Genome noted that Lightning had noticed that Varis was more hesitant than he had been before. After Varis ended his turn, Bohman took Jin and Specter's data from Lightning to allow them to Duel fairly. During the Duel, Lightning revealed that he had been the one who had infected Dr. Kogami with the computer virus; Genome realized in horror that the revenge of the Knights of Hanoi had been misplaced all along. Lightning ended the Duel in an apparent DRAW, much to Genome's horror and he watched in shock as Varis fragmented into data. However, Lightning had converted some of Jin's consciousness data into LP, allowing him to survive the Duel and give himself to Bohman, giving Bohman the data of five of the Ignis.[21]

Genome and Aso watched the final Duel between Playmaker and Bohman. Bohman caused an Ignis algorithm to appear in both LINK VRAINS and Mirror LINK VRAINS, which began striking people down, something Genome wondered might have been the doing of the Ignis. To Genome's shock, Bohman then Link Summoned a Link-5 monster, "Chimera Hydradrive Dragrid", which he explained he was creating using the capabilities of the victims of the algorithm he had created, the Neuron Link, a system that Genome decried as disgusting.[22] Clarissa ordered them to analyze the Neuron Link; Genome found the opportunity exciting, prompting Aso to tell him off for treating the situation like a game. Curious users began logging in and were trapped by the Neuron Link; Genome idly wondering why there were so many fools. Genome eventually deduced that the overlap between the two LINK VRAINS was the key to stopping the Neuron Link and the Commanders began looking into it. When Clarissa warned them that there would be more victims if Bohman used his Skill again, Aso suggested that the power Bohman had to use when activating his Skill could present a vulnerability in the Neuron Link for them to exploit. Genome was concerned the brief time Bohman used his Skill would not be long enough for them to attack the system, so Aso suggested they could attack the Neuron Link from inside and outside LINK VRAINS. Clarissa revealed that Akira Zaizen and Ghost Gal were in LINK VRAINS, so Aso contacted them to inform them of their plan.[23] Genome launched the Commanders' attack, and though it was successful, the Neuron Link trapped Zaizen and Ghost Gal after they launched their own attack. Bohman then began repairing the Neuron Link, so to Genome's shock, Ai sacrificed himself to stop it. He was horrified when Bohman revived "Dragrid" and bolstered it with "Judgment Arrows", believing Bohman would defeat Playmaker. Instead, despite Ai's sacrifice, Bohman used LINK VRAINS itself as data to restore the Neuron Link and obtain "Perfectron Hydradrive Dragon", reducing Playmaker to 100 LP.[24] Genome watched as Ai returned and Playmaker defeated Bohman with "Firewall Dragon Darkfluid".[25]


Genome and Aso left Café Nom after Bohman was defeated, before Kolter woke up. The Knights of Hanoi continued to monitor the network, willing to oppose Ai if he turned against humanity. Zaizen came to the Knights of Hanoi to request protection from Ai and Roboppi, who were targeting him for his code key to SOL Technologies. Varis agreed to help Zaizen, and that the Knights of Hanoi would turn themselves in after Ai had been dealt with, as their mission would be over. Genome joined Varis, Specter, Faust and Baira at the defunct Central Station, meeting with Zaizen, Blue Maiden, Soulburner, The Gore, Ghost Gal and The Shepherd. Genome was assigned to team with The Gore and the other Commanders to guard the western interior entrance. As they moved to cover their assigned positions, Playmaker finally arrived to join the battle.[26]

Genome and Baira were the first to encounter Ai directly after his three copies engaged Varis, Playmaker and Soulburner. Ai defeated them in a Speed Tag Duel easily, taking their data after he did so.[27] Genome was released after Playmaker defeated Ai, but the Knights did not turn themselves in, according to Soulburner's wishes after he had defeated Varis in a Duel.[28][29] Genome viewed their new role as protectors of LINK VRAINS as atonement for their past crimes.[29]


Genome plays a "Helixx" Deck. His strategy involves summoning high Level monsters without Tribute and using them for Link Summons, while also focusing on defensive effects, including damage prevention.


Opponent(s) Episode(s) Outcome
George Gore/The Gore 23-24 Lose
Echo 69 Win
Ai 106 Lose (with Baira)


  1. a b Yu-Gi-Oh! VRAINS episode 22: "The Deleted"
  2. Yu-Gi-Oh! VRAINS episode 43: "The Reveal"
  3. a b c Yu-Gi-Oh! VRAINS episode 23: "A Grim Tale"
  4. a b Yu-Gi-Oh! VRAINS episode 68: "The Doorway"
  5. Yu-Gi-Oh! VRAINS episode 24: "To Gore Or Not To Gore"
  6. Yu-Gi-Oh! VRAINS episode 29: "Kolter's Khronicles"
  7. Yu-Gi-Oh! VRAINS episode 46: "Link to the Future"
  8. Yu-Gi-Oh! VRAINS episode 59: "Return of the Hanoi"
  9. Yu-Gi-Oh! VRAINS episode 69: "Coexistence"
  10. Yu-Gi-Oh! VRAINS episode 70: "A Storm Brews"
  11. Yu-Gi-Oh! VRAINS episode 71: "A Logical Decision"
  12. Yu-Gi-Oh! VRAINS episode 84: "Payback"
  13. Yu-Gi-Oh! VRAINS episode 86: "The Weakest Link"
  14. Yu-Gi-Oh! VRAINS episode 87: "The Ultimate Connection"
  15. Yu-Gi-Oh! VRAINS episode 92: "Fight with a Friend"
  16. Yu-Gi-Oh! VRAINS episode 93: "A Fighting Promise"
  17. Yu-Gi-Oh! VRAINS episode 94: "No Matter What It Takes"
  18. a b Yu-Gi-Oh! VRAINS episode 95: "From the Ashes"
  19. Yu-Gi-Oh! VRAINS episode 96: "I Know Your Secret"
  20. Yu-Gi-Oh! VRAINS episode 97: "Outsmart, Outwit, Outthink!"
  21. Yu-Gi-Oh! VRAINS episode 98: "Lightning Storm"
  22. Yu-Gi-Oh! VRAINS episode 99: "Bohman's End Game"
  23. Yu-Gi-Oh! VRAINS episode 100: "I Know Everything"
  24. Yu-Gi-Oh! VRAINS episode 101: "Ai of the Beholder"
  25. Yu-Gi-Oh! VRAINS episode 102: "The Final Turn"
  26. Yu-Gi-Oh! VRAINS episode 105: "Unlikely Alliance"
  27. Yu-Gi-Oh! VRAINS episode 106: "Roboppi Mops Up"
  28. Yu-Gi-Oh! VRAINS episode 117: "Parallel Paths"
  29. a b Yu-Gi-Oh! VRAINS episode 120: "Connected World"